The impact of regulatory factors on the TGF-β pathway on posterior capsule opacification

doi:10.3760/ cma.j.issn.1673-5803.2024.02.002

International Review of Ophthalmology ›› 2024, Vol. 48 ›› Issue (2): 87-92.doi: 10.3760/ cma.j.issn.1673-5803.2024.02.002

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The impact of regulatory factors on the TGF-β pathway on posterior capsule opacification

Xu Su, Zhang Yuhang, Si Wei, Zhang Fengyan

Department of Ophthalmology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000

Received:2023-10-11 Online:2024-04-22 Published:2024-04-29
Contact: Zhang Fengyan, Email:zhangfengyanx@aliyun.com
Supported by:
National Natural Science Foundation of China (81970785)

Abstract

Abstract: Posterior capsule opacification (PCO) is the primary cause of compromised visual acuity in patients following cataract surgery, with an incidence ranging from 30% to 50% in adults and up to 100% in children. The pathogenic mechanism of PCO is complex. The TGF-β pathway influences the epithelial-mesenchymal transition and migration of lens epithelial cells. The expression of certain ribonucleic acids, autophagy or apoptosis can exert influence on PCO formation, thereby leading to the identification of potential therapeutic agents for its prevention. (Int Rev Ophthalmol, 2024, 48: 87-92)

Key words: posterior capsule opacification, transforming growth factor beta, lens

Xu Su, Zhang Yuhang, Si Wei, Zhang Fengyan. The impact of regulatory factors on the TGF-β pathway on posterior capsule opacification [J]. International Review of Ophthalmology, 2024, 48(2): 87-92.

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The impact of regulatory factors on the TGF-β pathway on posterior capsule opacification

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